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Intergenic Sequences (IGS) Myoclobin Protein
The genome has coding and non–coding regions. The coding regions are transcribed; the non-coding regions constitute regulatory sequences and intergenic sequences the function of most of which is yet to be known.
Why Intergenic Sequences from E. coli?
Intergenic sequences are considered as genetic fossils that were useful sometime in the evolutionary past1. There are also reports which support the creation of new genes from the non–coding regions of the genome2–4. The ENCODE pilot project on human genome brought out astounding revelations that non–coding intergenic sequences are actively transcribed and have a role in regulation of gene expression, DNA replication and chromosome structure5,6. E. coli is a model prokaryote with a small genome with a smaller proportion as IGS. Therefore a database with results of comprehensive analysis of the coding and regulatory potential of intergenic sequences in E. coli has been created.
Creation of the database more


References:
1.
So much "junk" DNA in our genome, Ohno S., Brookhaven Symp Biol., 1972; 23: 366-370. (Alternate Link)
2. De Novo Origination of a New Protein-Coding Gene in Saccharomyces cerevisiae, Cai J., et al., Genetics, 2008; 179: 487-496.
3. Recent de novo origin of human protein-coding genes, The ENCODE Project Consortium, Knowles D. G. and McLysaght A., Genome Res., 2009; 19: 1752-1759.
4. The origin of new genes: glimpses from the young and old, Long M., et al., Nat Rev Gen, 2003; 4: 865-875.
5. The ENCODE (ENCyclopedia Of DNA Elements) Project, The ENCODE Project Consortium., Science, 2004; 306: 636-640.
6. ENCODE whole-genome data in the UCSC Genome Browser, Rosenbloom K. R., et al., Nucl. Acids Res. 2010; 38: 620-625.


Acknowledgements:
Thanks to CSIR and UGC for SRF and RFSMS-JRF.
Thanks to Biologistics for the system support during the beginning of my work.
Thanks to all my colleagues at lab who gave me valuable inputs while designing the database.


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© Sathi Ravi Kanth Reddy, 2019